Takasugi Shinsaku is the best friend of Katsura Kogorō who opposed his friend's recruit of a young boy named Himura Kenshin as Hitokiri Battōsai. Takasugi belived that Kenshin suffered deeply as assassin, due to him having to take away the lives of others in order to create the new Meiji era.

As the commander of the Revolution's armies, he's said to lead his men like the very god of war himself.

He suffers from tuberculosis, which causes him to become a social outcast, only ever kept company by his partner Uno.

He dies right outside the last battle of the Revolution; his "death poem" was "I made an interesting place out of our boring lonely world."

He was voiced by Wataru Takagi in the Japanese version.

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